View Filing Data

(167,226)

(158,775)

^[1]

Total equity

^[1]

92,872

56,592

Non-current liabilities

Taxes and social security liabilities

105,718

112,551

^[1]

Current liabilities

Trade payables

5,433

2,855

^[1]

100

243

^[1]

Other liabilities and accruals

16,972

15,935

^[1]

10,860

8,627

^[1]

Current liabilities

33,365

27,660

^[1]

Total liabilities

139,083

140,211

^[1]

Total equity and liabilities

€ 231,955

€ 196,803

^[1]

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Unaudited Condensed Consolidated Statement of Profit or Loss and Comprehensive Loss - EUR (€)
€ in Thousands

3 Months Ended

6 Months Ended

Jun. 30, 2018

Jun. 30, 2017

^[1]

Jun. 30, 2018

Jun. 30, 2017

^[1]

Operating expenses from railroad and related business [abstract]

Research and development costs

€ 6,543

€ 6,237

€ 16,464

€ 10,121

(12,523)

(8,420)

(22,821)

(15,427)

Management and administration costs

(2,639)

(3,492)

(5,491)

(7,694)

Other expenses

(3,297)

(2,277)

(5,983)

(4,120)

Total operating expenses

(18,459)

(14,189)

(34,295)

(27,241)

Net finance income / (expense)

(11,916)

(7,952)

(17,831)

(17,120)

Finance income

7,411

420

4,945

610

Finance cost

(1)

(11,962)

(1)

(22,696)

7,410

(11,542)

4,944

(22,086)

Result before taxation

(4,506)

(19,494)

(12,887)

(39,206)

Income tax expense

(87)

(107)

(139)

(118)

Exchange differences from the translation of foreign operations

(4,593)

(19,601)

(13,026)

(39,324)

Other comprehensive income

Total other comprehensive income for the period

€ (4,557)

€ (19,588)

€ (13,005)

€ (39,306)

Weighted average shares outstanding Basic (and diluted)

^[2]

€ (0.20)

€ (1.01)

€ (0.60)

€ (2.07)

^[2]

22,628,611

19,392,495

21,809,950

18,976,446

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.
[2]	For the periods included in these financial statements, share options were excluded from the diluted loss per share calculation as the Company was in a loss position in each period presented above. As a result, basic and diluted loss per share is equal.

Unaudited Condensed Consolidated Statement of Changes in Equity - EUR (€)
€ in Thousands

Total

Issued capital [member]

Share premium [member]

Accumulated loss [member]

Beginning balance (Previously stated [member]) at Dec. 31, 2016

€ 34,031

€ 1,448

€ 139,878

€ (107,295)

Beginning balance (Increase (decrease) due to application of IFRS 15 [member]) at Dec. 31, 2016

390

Beginning balance at Dec. 31, 2016

^[1]

34,421

1,448

139,878

(106,905)

Result after taxation for the period | Previously stated [member]

(43,132)

Result after taxation for the period | Increase (decrease) due to application of IFRS 15 [member]

3,808

Result after taxation for the period

(39,324)

^[1]

(39,324)

Other comprehensive income

^[1]

Total comprehensive loss for the period | Previously stated [member]

(43,114)

Total comprehensive loss for the period | Increase (decrease) due to application of IFRS 15 [member]

3,808

Transactions with owners of the Company:

(39,306)

^[1]

(39,306)

Issuance of shares (net)

73,961

298

73,663

Equity settled shared-based payments

7,880

Total contributions by owners

81,841

298

73,663

7,880

Ending balance at Jun. 30, 2017

^[1]

76,956

1,746

213,541

(138,331)

Beginning balance (Previously stated [member]) at Dec. 31, 2017

47,887

1,749

213,618

(167,480)

Beginning balance (Increase (decrease) due to application of IFRS 15 [member]) at Dec. 31, 2017

8,705

Beginning balance at Dec. 31, 2017

^[1]

56,592

1,749

213,618

(158,775)

Result after taxation for the period

(13,026)

Other comprehensive income

Transactions with owners of the Company:

(13,005)

Issuance of shares (net)

44,731

288

44,443

Equity settled shared-based payments

4,554

Total contributions by owners

49,285

288

44,443

4,554

Ending balance at Jun. 30, 2018

^[1]

€ 92,872

€ 2,037

€ 258,061

€ (167,226)

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Unaudited Condensed Consolidated Statement of Cash flows
€ in Thousands, $ in Millions

6 Months Ended

Jun. 30, 2018

EUR (€)

Jun. 30, 2017

EUR (€)

Cash flows from operating activities

Changes in fair value derivative

€ (13,026)

€ (39,324)

^[1]

Adjustments for:

^[1]

10,667

Unrealized foreign exchange results

(3,648)

12,357

^[1]

Depreciation and amortization

218

147

^[1]

Share-based payment expenses

4,554

7,880

^[1]

Net finance (income) expenses

(531)

(593)

^[1]

Cash flows from (used in) operations before changes in working capital

(12,433)

(8,866)

^[1]

Taxes and social security assets

^[1]

(2,024)

Trade and other receivables

(959)

(1,946)

^[1]

Other assets

(38)

Trade payables

2,307

1,673

^[1]

Other liabilities and accruals

2,233

1,784

^[1]

Taxes and social security liabilities

(5,796)

(6,899)

^[1]

(143)

719

^[1]

Cash used in operations

(14,829)

(15,559)

^[1]

Interest paid

(1)

(5)

^[1]

Taxes paid

(302)

(12)

^[1]

Net cash used in operating activities

(15,132)

(15,576)

^[1]

Cash flow from investing activities

Purchases of investments

(29,560)

Proceeds from investment maturities

18,931

Purchase of intellectual property

(100)

Acquisition of property, plant and equipment

(624)

(525)

^[1]

Interest received

602

496

^[1]

Net cash used in investing activities

(10,751)

(29)

^[1]

Cash flow from financing activities

Proceeds from issuing shares, net of issuance costs

44,731

74,431

^[1]

Proceeds from stock option exercises

^[1]

227

Proceeds from collaboration and license agreement

^[1]

111,993

Repayment of borrowings

^[1]

(486)

Increase in restricted cash

^[1]

167

Net cash from financing activities

44,731

186,332

^[1]

Net increase in cash and cash equivalents

18,848

170,727

^[1]

Effects of exchange rate changes on cash and cash equivalents

1,801

(11,856)

^[1]

Cash and cash equivalents as at beginning of period

^[1]

149,678

56,917

Cash and cash equivalents as at end of period

170,327

€ 215,788

^[1]

Changes in accrued capital expenditures

€ 271

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

General information

6 Months Ended

Jun. 30, 2018

General information

1.	General information

Merus N.V. is a clinical-stage immuno-oncology company developing innovative bispecific antibody therapeutics, headquartered in Utrecht, the Netherlands. Merus US, Inc. is a wholly-owned subsidiary of Merus N.V. located in Boston, Massachusetts, United States. These condensed consolidated interim financial statements as at and for the three- and six-month periods ended June 30, 2018, comprise Merus N.V. and Merus US, Inc. (collectively, the “Company”).

On February 13, 2018, the Company entered into a Securities Purchase Agreement (the “Purchase Agreement”) with the purchasers named therein (the “Investors”). Pursuant to the Purchase Agreement, the Company agreed to sell an aggregate of 3,099,997 of its common shares, nominal value €0.09 per share (the “Common Shares”), to the Investors for aggregate gross proceeds of approximately $55.8 million, at a purchase price equal to $18.00 per share (the “Private Placement”). The Purchase Agreement contained customary representations and warranties from the Company and the Investors and customary closing conditions. On February 15, 2018, the Company completed the sale under the Private Placement and received aggregate gross proceeds of approximately $55.8 million.

Nature of Business

The Company expects to continue to incur significant expenses and operating losses for the foreseeable future as its bispecific antibody candidates advance through discovery, preclinical development and clinical trials, and as it seeks regulatory approval and pursues commercialization of any approved bispecific antibody candidate.

As a result, the Company may need additional financing to support its continuing operations. Until the Company can generate significant revenue from product sales, if ever, the Company expects to finance its operations through public equity, debt financings, or other sources, which may include collaborations with third parties. Adequate additional financing may not be available to the Company on acceptable terms, or at all. The Company’s inability to raise capital as and when needed would have a negative impact on its financial condition and ability to pursue its business strategy. The Company will need to generate significant revenues to achieve profitability and may never do so.

Based on the Company’s current operating plan, it expects its existing cash balances and investments to last through the end of 2020. For this assessment, the Company has taken into consideration its existing cash and cash equivalents of €170.3 million, which include the $55.8 million, or €44.8 million, in proceeds received from the Private Placement offering that closed in February 2018, and investments of €53.7 million as of June 30, 2018.

Significant accounting policies

6 Months Ended

Jun. 30, 2018

Significant accounting policies

2.	Significant accounting policies

There have been no significant changes to the Company’s accounting policies that were previously disclosed in its Annual Report on Form 20-F for its fiscal year ended December 31, 2017, or in the methodology used in formulating these significant judgments and estimates that affect the application of these policies, except for the adoption of new accounting standards as disclosed more fully in Note 3.

Basis of Presentation

These unaudited interim condensed consolidated financial statements (the “interim financial statements”) have been prepared in accordance with International Accounting Standard 34 “Interim Financial Reporting” as issued by the International Accounting Standards Board (“IASB”). Certain information and disclosures normally included in financial statements prepared in accordance with International Financial Reporting Standards (“IFRS”) have been condensed or omitted. Accordingly, these interim financial statements should be read in conjunction with the Company’s annual financial statements for the year ended December 31, 2017. In the opinion of management, all adjustments (consisting of a normal recurring nature) considered necessary for a fair presentation have been included in the interim financial statements. All intercompany transactions and balances are eliminated in consolidation.

Use of Estimates

The preparation of financial statements in conformity with IFRS requires the use of certain critical accounting estimates. It also requires management to exercise its judgment in the process of applying the Company’s accounting policies. The areas involving a higher degree of judgment or complexity or areas where assumptions and estimates are significant to these interim financial statements are disclosed in Note 4. The results of operations for the three- and six-month periods ended June 30, 2018, are not necessarily indicative of operations to be expected for the full fiscal year ending December 31, 2018.

Foreign Currency Transactions

Items recorded in each of the Company’s entities are measured using the currency of the primary economic environment in which the entity operates (the “functional currency”). The interim financial statements are presented in euros, which is Merus N.V.’s functional currency. The functional currency of Merus US, Inc. is the U.S. dollar. All amounts are rounded to the nearest thousand euros, except where otherwise indicated. Foreign currency gains and losses are reported on a net basis as either finance income or finance expense depending on whether foreign currency movements are in a net gain or net loss position.

Seasonality

The Company’s financial results have varied substantially, and are expected to continue to vary, from period to period. The Company believes that its ordinary activities are not linked to any particular seasonal factors.

Segment Reporting

The Company operates in one reportable segment, which comprises the discovery and development of innovative bispecific therapeutics.

Cash and Cash Equivalents

For the purpose of presentation in the statement of cash flows as well as the statement of financial position, cash and cash equivalents include deposits held with financial institutions with original maturities of less than three months. Cash and cash equivalents include €34.3 million of short-term investments with a three-month or less maturity, callable on demand. The carrying values of short-term investments approximate fair value due to their short-term maturities.

Revenue Recognition

The Company enters into collaboration agreements which are within the scope of IFRS 15—Revenue from Contracts with Customers (“IFRS 15”), under which the Company licenses rights to certain of the Company’s product candidates and performs research and development services. The terms of these arrangements typically include payment of one or more of the following: non-refundable, upfront fees; reimbursement of research and development costs; development, regulatory, and commercial milestone payments; and royalties on net sales of licensed products.

IFRS 15 requires an entity to recognize the amount of revenue to which it expects to be entitled for the transfer of promised goods or services to customers. Under IFRS 15, the Company recognizes revenue when its customer obtains control of the goods or services, in an amount that reflects the consideration that the Company determines it expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of IFRS 15, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies the performance obligation. The Company applies the five-step model to contracts only when it is probable that it will collect the consideration to which it is entitled in exchange for the goods or services it transfers to the customer. As part of the accounting for these arrangements, the Company must make significant judgments, including identifying performance obligations in the contract, estimating the amount of variable consideration to include in the transaction price and allocating the transaction price to each performance obligation.

The Company currently generates a portion of its revenue through collaboration and license agreements with strategic collaborators for the development and commercialization of product candidates. The collaboration and license agreements are within the scope of IFRS 15.

Up-front License Payments

If the license to the Company’s intellectual property is determined to be distinct from the other performance obligations identified in the agreement, the Company recognizes revenues from non-refundable, up-front fees allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license. If not distinct, the license is combined with other performance obligations in the contract. For licenses that are combined with other performance obligations, the Company assesses the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purpose of recognizing revenue. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition.

Pursuant to the Company’s research and license agreements with its collaborators, the Company has received upfront license payments relating to the integrated packages of deliverables under the contracts. Each contract contains either one single performance obligation or multiple performance obligations that the up-front consideration was allocated to. These upfront license payments are initially recorded in deferred revenue on the consolidated statements of financial position and are recognized as revenue on either: (i) a straight-line basis over the period of the related performance obligation or the contractual term of the arrangement; or (ii) based on another appropriate depiction of the Company’s performance over the period of the related performance obligation or the contractual term, such as costs incurred relating to full-time equivalent research employees. The applicable period over which to recognize the upfront payment is a significant judgment, which is re-assessed at each reporting date.

Collaboration Income

Collaboration income, which is typically related to reimbursements from collaborators for the Company’s performance of research and development services under the respective agreements, is recognized on the basis of labor hours valued at a contractually agreed rate. Collaboration income includes reimbursements for related out-of-pocket expenses. Cost reimbursements to which the Company is entitled under agreements are recognized as revenue in the same period as the cost for which they are intended to compensate. The Company acts as the principal and therefore records these reimbursements as collaboration income.

In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under the agreements, the Company performs the five steps listed above. As part of the accounting for the arrangement, the Company must develop assumptions that require judgment to determine the stand-alone selling price for each performance obligation identified in the contract. The Company uses key assumptions to determine the stand-alone selling price, which may include market conditions, reimbursement rates for personnel costs, development timelines and probabilities of regulatory success.

The Company capitalizes the incremental costs of obtaining a contract with a customer if it expects to recover those costs. Such incremental costs would not have been incurred if the contract with a customer had not been obtained. To date, the Company has not capitalized any incremental costs for obtaining a contract.

The Company’s contracts often include development and regulatory milestone payments which are assessed under the most likely amount method and constrained if it is probable that a significant revenue reversal would occur. Milestone payments that are not within the Company’s control or the licensee’s control, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. At each reporting date, the Company re-evaluates the probability of achievement of development milestones and any related constraint, and if necessary, adjusts the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect collaboration revenues in the period of adjustment.

For agreements that include sales-based royalties, including milestone payments based on the level of sales, and the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). To date, the Company has not recognized any consideration related to sales-based royalty revenue resulting from any of the Company’s collaboration agreements.

Government Grants

The Company receives certain government and regional grants, which support its research efforts in defined projects, and include contributions towards the cost of research and development. When there is reasonable assurance that the Company will comply with the conditions attached to a received grant, and when there is reasonable assurance that the grant will be received, government grants are recognized as revenue on a gross basis in the consolidated statement of profit or loss and comprehensive loss on a systematic basis over the periods in which the Company recognizes expenses for the related costs for which the grants are intended to compensate. In the case of grants related to assets, the received grant will be deducted from the carrying amount of the asset.

Reclassifications

Certain amounts were reclassified in the prior period condensed consolidated interim financial statements to conform to the current period presentation.

Recently Issued International Financial Reporting Standards

6 Months Ended

Jun. 30, 2018

Recently Issued International Financial Reporting Standards

3.	Recently Issued International Financial Reporting Standards

Except as otherwise indicated, the accounting policies adopted in the preparation of these interim financial statements are consistent with those applied in the preparation of the Company’s annual financial statements for the year ended December 31, 2017.

Standards implemented since December 31, 2017

Revenue from Contracts with Customers—IFRS 15

In May 2014, the IASB issued IFRS 15, which supersedes existing revenue recognition guidance. Prior to the adoption of IFRS 15, revenue was recognized to the extent that it was probable that the economic benefits would flow to the Company and the revenue could be reliably measured. The new standard requires an entity to recognize the amount of revenue to which it expects to be entitled for the transfer of promised goods or services to customers. To achieve that core principle, an entity must identify the contract(s) with a customer, identify the performance obligations in the contract, determine the transaction price, allocate the transaction price to the performance obligations in the contract, and recognize revenue when (or as) the entity satisfies the performance obligation. IFRS 15 is effective for annual and interim reporting periods beginning on or after January 1, 2018 and should be applied retrospectively to each prior reporting period presented or retrospectively with the cumulative effect of initially applying this update recognized at the date of initial application.

The adoption of IFRS 15 impacts the amortization of the Company’s up-front license payments. The Company previously recognized revenue from up-front license payments on a straight-line basis over the contractual term or the period of continuing involvement which was previously estimated to be 21 years for the collaboration and license agreement the Company entered into with Incyte Corporation (“Incyte”) on December 20, 2016 (the “Incyte collaboration and license agreement”), and 4.5 years for the research and license agreement the Company entered into with ONO Pharmaceutical Co., Ltd. (“ONO”) on April 8, 2014 (the “ONO research and license agreement”). In applying IFRS 15, the Company has evaluated the distinct performance obligations in each agreement. Specifically, for Incyte, the total period for which the Company expects to provide access to its proprietary technology is currently estimated to be nine years, which is the research term initially agreed to in the Incyte collaboration and license agreement.

The Company adopted the new standard effective January 1, 2018, using the retrospective method, with the effect of initially applying this standard recognized at the beginning of the earliest period presented. The Company had two open contracts on the adoption date and has assessed these contracts under the new revenue standard. In addition, the Company elected to apply the practical expedient to not apply this guidance to contracts that were completed before the beginning of the earliest period presented, or January 1, 2016, and the practical expedients for contract modifications (assessing the contracts in combination with any modifications before January 1, 2017). Under the practical expedient, the Company excluded certain option and exclusivity agreements that expired in 2015 and 2014, respectively. As a result of the adoption of IFRS 15, prior year financial statements have been restated. The Company has accounted for the impact of adopting IFRS 15 as a cumulative catch-up as a decrease of approximately €8.7 million to deferred revenue with an offset to accumulated deficit, effective January 1, 2018.

The following financial statement line items have been shown to reflect the adjustments recognized for each individual line item in the Company’s respective consolidated statements for the period noted:

Condensed Consolidated Statement of Profit or Loss and Comprehensive Loss


	Three months ended June 30, 2017 (As originally presented)			IFRS 15 Adoption		Three months ended June 30, 2017 Restated
	(euros in thousands)
Revenue		4,027			2,210		6,237
Operating result		(10,162	)		2,210		(7,952	)
Total comprehensive loss for the period		(21,798	)		2,210		(19,588	)
Basic (and diluted) loss per share		(1.12	)		0.11		(1.01	)


	Six months ended June 30, 2017 (As originally presented)			IFRS 15 Adoption		Six months ended June 30, 2017 Restated
	(euros in thousands)
Revenue		6,313			3,808		10,121
Operating result		(20,928	)		3,808		(17,120	)
Total comprehensive loss for the period		(43,114	)		3,808		(39,306	)
Basic (and diluted) loss per share		(2.27	)		0.20		(2.07	)

Condensed Consolidated Statement of Financial Position


	December 31, 2017 As originally presented			IFRS 15 Adoption			December 31, 2017 Restated
	(euros in thousands)
Accumulated loss		(167,480	)		8,705			(158,775	)
Deferred revenue, non-current		130,195			(17,644	)		112,551
Deferred revenue		6,996			8,939			15,935

Condensed Consolidated Statement of Cash Flows


	June 30, 2017 As originally presented			IFRS 15 Adoption			June 30, 2017 Restated
	(euros in thousands)
Result after taxation		(43,132	)		3,808			(39,324	)
Changes in working capital:
Deferred revenue		(3,091	)		(3,808	)		(6,899	)

Financial Instruments—IFRS 9

IFRS 9- Financial Instruments (“IFRS 9”) replaces the provisions of IAS 39 that relate to the recognition, classification and measurement of financial assets and financial liabilities, derecognition of financial instruments, impairment of financial assets and hedge accounting. IFRS 9 also significantly amends other standards dealing with financial instruments such as IFRS 7 Financial Instruments: Disclosures. The Company assessed the classification and measurement of the financial instruments it held at the date of initial application of IFRS 9, or January 1, 2018, and has classified its financial instruments into the appropriate IFRS 9 categories. There were no changes to the carrying value of the Company’s financial instruments resulting from this reclassification and accordingly there was no impact to the Company’s opening accumulated deficit at January 1, 2018, as a result of the adoption of IFRS 9.

Standard issued but not yet effective

The IASB has issued a new standard on leases that will require lessees to recognize most leases on their balance sheets as lease liabilities with a corresponding right-of-use asset. The IASB has set an effective date to apply the new standard for periods beginning on or after January 1, 2019. The Company is assessing all effective agreements to determine whether there are embedded leases included under the definition in IFRS 16. Early adoption is permitted; however, the Company expects to adopt this standard in the first quarter of 2019. The Company is evaluating the impact that this guidance will have on the Company’s financial statements, including related disclosures, and expects the new standard to impact its internal controls, systems, and processes.

Use of Estimates, Judgments and Assumptions

6 Months Ended

Jun. 30, 2018

Use of Estimates, Judgments and Assumptions

4.	Use of Estimates, Judgments and Assumptions

In the application of the Company’s accounting policies, management is required to make judgments, estimates and assumptions that affect the reported amounts of assets, liabilities, income and expenses that are not readily apparent from other sources. The estimates and associated assumptions are based on historical experience and other factors that are considered to be relevant. Actual results may differ from these estimates.

Estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognized prospectively.

The following are the critical judgments and assumptions that management has made in the process of applying the Company’s accounting policies and that have the most significant effect on the amounts recognized in the interim financial statements.

Equity settled share-based payments

Share options granted to employees, consultants and directors are measured at the grant date fair value of the equity instruments granted. The grant date fair value is determined through the use of an option-pricing model considering the following variables:

(a)

the exercise price of the option;

(b)

the expected life of the option;

(c)

the current value of the underlying shares;

(d)

the expected volatility of the share price;

(e)

the dividends expected on the shares; and

(f)

the risk-free interest rate for the life of the option.

The estimated fair value of each share option granted was determined utilizing the Hull & White option pricing model, which considers the terms and conditions attached to the grants made and is reflective of expected exercise behavior. Because the Company’s shares have been publicly traded for a relatively short amount of time, the expected volatility was set by also giving weight to the historic share price volatility of a set of peer companies. The continuous yield on U.S. Treasury Bills with a term to maturity comparable to the expected life of the options, as published by the U.S. Department of Treasury, was applied.

The result of the share option valuations and the related compensation expense that is recognized for the respective vesting periods during which services are received are dependent on the model and input parameters used. Even though management considers the fair values reasonable and defensible based on the methodologies applied and the information available, others might derive a different fair value for the Company’s share options. These assumptions and estimates are further discussed in Note 9 to the financial statements.

Capitalization of development costs

The criteria for capitalization of development costs have been considered by management and determined not to have been met in the second quarter of 2018. Therefore, all development expenditures relating to internally generated intangible assets in 2018 were expensed as incurred.

Income taxes

As of June 30, 2018, deferred tax assets have not been recognized in respect of tax losses as the Company has no history of generating taxable profits. Therefore, at the balance sheet date, there is no convincing evidence that sufficient taxable profit will be available against which the tax losses can be utilized.

Merus US, Inc., which is incorporated in the United States in the State of Delaware, is subject to statutory U.S. Federal corporate income taxes and state income taxes for Massachusetts. Current year income tax expense was attributable entirely to Merus US, Inc. which provides general management services and strategic advisory services to the Company. Corporate income tax expenses were €0.1 million for the three- and six-month periods ended June 30, 2018, as compared to €0.1 million for the three- and six-month periods ended June 30, 2017.

Deferred revenue

Pursuant to the Company’s research, collaboration and license agreements with ONO, Incyte, and Jiangsu Simcere Pharmaceutical Co. Ltd. (“Simcere”), the Company has received upfront non-refundable payments for certain rights granted under the respective agreements. The applicable period over which to recognize these upfront payments requires significant judgment and was impacted by the adoption of IFRS 15 (See Note 3 and Note 8).

Revenue related to ONO upfront payments is deferred and amortized based on a measure of progress in delivering research services under the contract. Revenue related to Incyte and Simcere upfront payments is deferred and amortized on a straight-line basis over the estimated research term (See Note 3 and Note 8).

Research and development expenses

Research and development expenses represent costs that primarily include: (i) payroll and related costs (including share-based payment expenses) associated with research and development personnel; (ii) costs related to clinical trials and preclinical testing of the Company’s technologies under development; (iii) costs to develop product candidates, including raw materials and supplies, product testing, depreciation, and facility related expenses; (iv) expenses for research services provided by universities and contract laboratories; and (v) other research and development expenses. Research and development expenses are recognized in the consolidated statement of profit or loss and comprehensive loss as incurred when these expenditures relate to the Company’s research and development services and have no alternative future uses.

The Company has entered into various research and development contracts with research institutions and other companies. These agreements are generally cancelable. The Company records accruals for estimated ongoing research costs. When evaluating the adequacy of the accrued liabilities, the Company analyzes progress of the studies, including the phase or completion of events, invoices received and contracted costs. Significant judgments and estimates may be made in determining the accrued balances at the end of any reporting period. Actual results could differ from the Company’s estimates. The Company’s historical accrual estimates have not been materially different from the actual costs.

Investments

6 Months Ended

Jun. 30, 2018

Investments

5.	Investments

On January 1, 2018, the Company adopted IFRS 9 and classifies and accounts for its investments at amortized cost. The Company’s investments as of December 31, 2017, were classified and accounted for as held-to-maturity under IAS 39. The initial adoption of IFRS 9 had no impact on previously reported amounts (See Note 3). IFRS 9 replaces the ‘incurred loss’ model in IAS 39 with an ‘expected credit loss’ (“ECL”) model. The new impairment model applies to financial assets measured at amortized cost, contract assets and debt investments at fair value through other comprehensive loss, but not to investments in equity instruments. Under IFRS 9, credit losses are recognized earlier than under IAS 39. Under IFRS 9, loss allowances are measured on either 12-month ECLs which result from possible default events within the 12 months after the reporting date or lifetime ECLs which result from all possible default events over the expected life of a financial instrument.

The Company’s financial assets recorded at amortized cost consist of cash and cash equivalents, investments and trade and other receivables. These financial assets are considered to have a low credit risk and, as such, there was no impact to the Company’s opening accumulated deficit as a result of the change in impairment methodology.

The Company’s investments include investments in commercial paper, securities issued by several public corporations and the United States Treasury. Current investments include investments with a maturity date of greater than three months at the date of settlement. Investments with a maturity of 12 months or more from the original investment date are classified as non-current.

Investments as of June 30, 2018, and December 31, 2017, consist of the following:


	Balance as per
	June 30, 2018		December 31, 2017
	(euros in thousands)
Commercial paper		17,715		15,527
U.S. Treasury securities		2,574		9,177
Corporate fixed income bonds		15,289		7,886
Agency bond		1,499		1,453

Investments, current portion		37,077		34,043
Corporate fixed income bonds		16,650		7,060

Non-current investments		16,650		7,060

Total investments		53,727		41,103

During the six-month period ended June 30, 2018, the Company purchased investments totaling €29.6 million, which are held and denominated in U.S. dollars, and received proceeds of €18.9 million relating to investment maturities. As a result of the fluctuation in foreign currency between the euro and U.S. dollar, the Company recorded foreign currency exchange gains of approximately €3.1 million and €1.9 million as a component of finance income / (expense) for the three- and six-month periods ended June 30, 2018, respectively.

Trade and Other Receivables

6 Months Ended

Jun. 30, 2018

Trade and Other Receivables

6.	Trade and Other Receivables

Trade and other receivables are short-term and due within 1 year.


	Balance as per
	June 30, 2018		December 31, 2017
	(euros in thousands)
Trade receivables		2,069		1,594
Unbilled receivables		446		710
VAT receivable		622		582
Prepaid expenses		1,640		427
Prepaid pension costs		359		838
Interest bank		275		170
Other receivables		66		92

		5,477		4,413

Trade and unbilled receivables relate primarily to invoicing for cost reimbursements relating to the Incyte collaboration and license agreement and the ONO research and license agreement. VAT receivable relates to value added tax receivable from the Dutch tax authorities based on the tax application for the second quarter of 2018.

Prepaid expenses reflected above in the form of prepaid expenses and prepaid pension costs consist of expenses that were paid during the reporting period but are related to activities taking place in subsequent periods. The increase in prepaid expenses at June 30, 2018 relate primarily to advanced payments made to contract research and contract manufacturing organizations in support of the Company’s upcoming clinical trial activities.

Other Liabilities and Accruals

6 Months Ended

Jun. 30, 2018

Other Liabilities and Accruals

7.	Other Liabilities and Accruals

All amounts are short-term and payable within 1 year.


	Balance per
	June 30, 2018		December 31, 2017
	(euros in thousands)
Accrued auditor’s fee		90		96
Personnel		315		446
R&D costs		8,777		5,272
IP – Legal fee		128		509
Bonuses		940		1,545
Subsidy advance received		145		224
Other accruals		465		535

		10,860		8,627

The research and development costs relate to accrued expenses for costs of certain development activities, such as clinical trials, and are recorded based on an evaluation of the progress to completion of specific tasks using data such as patient enrollment, clinical site activations, and information provided the Company by vendors on their actual costs incurred. The increase in research and development costs accrued expenses reflect the timing of enrollment in and support of the Company’s clinical trials, manufacturing of drug candidates used for clinical purposes, pre-clinical research efforts to support the Company’s internal research programs and the Incyte collaboration and license agreements and other collaboration agreements.

The bonuses relate to the employee bonuses for the financial year 2018, which will be paid out in February 2019. The decrease in bonuses accrual compared to December 31, 2017, related to the annual payment of the 2017 bonuses in the first quarter of 2018.

The subsidy advances received relate to active grants where the Company has received cash in excess of allowances which is required to be repaid or recognized as grant income when the relevant reimbursable costs are incurred as services are performed.

Deferred Revenue

6 Months Ended

Jun. 30, 2018

Deferred Revenue

8.	Deferred Revenue

Deferred revenue as of June 30, 2018, and December 31, 2017, consist of the following:


	Balance per
	June 30, 2018		December 31, 2017 Restated*
	(euros in thousands)
Deferred revenue – current portion		16,972		15,935
Deferred revenue		105,718		112,551

		122,690		128,486

*	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Of the total deferred revenue balance at June 30, 2018, €120.6 million related to the Incyte collaboration and license agreement and a share subscription agreement entered into by the Company with Incyte on December 20, 2016 (together, the “Incyte Agreements”), €2.0 million related to the collaboration and license agreement entered into by the Company with Simcere on January 8, 2018 (the “Simcere collaboration and license agreement”), and €0.1 million related to the ONO research and license agreement. The total deferred revenue balance at December 31, 2017, related solely to the Incyte Agreements.

Under the Incyte collaboration and license agreement, Incyte agreed to pay the Company a $120 million non-refundable upfront payment, and under the share subscription agreement, Incyte agreed to purchase 3.2 million Common Shares at a price per share of $25.00, for an aggregate purchase price of $80 million. In January 2017, the Company completed the sale of its Common Shares under the share subscription agreement and received the $80 million aggregate purchase price. In February 2017, the Company received the $120 million non-refundable upfront payment.

As the contract for the share subscription agreement was denominated in U.S. dollars, the Company determined that the forward contract to sell its own shares at a future date to which the Company became committed on December 20, 2016, represented a derivative financial instrument. The fair values of the derivative, or €31.4 million, and the non-refundable upfront payment, or €112.0 million, were recorded as deferred revenue. The Company identified a single performance obligation, providing access to its proprietary technology, relating to the Incyte Agreements and allocated all of the consideration received to this obligation. Both the upfront license payment and the derivative financial asset are being amortized as revenue over time by measuring the progress toward the complete satisfaction of a performance obligation or specifically, the total period for which the Company expects to provide access to its proprietary technology under the Incyte Agreements, which is currently estimated to be nine years in total, of which approximately 7.5 years remain.

Under the Simcere collaboration and license agreement, the Company agreed to grant Simcere an exclusive license to develop and commercialize in China three bispecific antibodies utilizing the Company’s Biclonics^® technology platform in the area of immuno-oncology. The Company will retain all rights outside of China. As part of the agreement, the Company has agreed to lead research and discovery activities while Simcere has agreed to be responsible for the Investigational New Drug enabling studies, clinical development, regulatory filings and commercialization of these product candidates in China. The Company received an upfront, non-refundable payment of $2.75 million, or €2.3 million, relating to three separate research programs. Each research program was determined to be a separate performance obligation and consideration was allocated to each separate obligation.

The Company will amortize the upfront payment to revenue over time based on the estimated duration of each research program. As of June 30, 2018, the first research program had commenced. For the three- and six-month periods ended June 30, 2018, the Company recognized revenue of €0.3 million relating to this program for both amortization of upfront payments and the achievements of milestones. The remaining two research programs had not commenced as of June 30, 2018. Accordingly, no revenue has been recognized related to the remaining two research programs.

On March 14, 2018, the Company entered into a second contract research and license agreement with ONO (the “second ONO research and license agreement”). Pursuant to an exclusive option granted to ONO in the ONO research and license agreement, ONO exercised its option to enter into the second ONO research and license agreement. The Company granted ONO an exclusive, worldwide, royalty-bearing license, with the right to sublicense, research, test, make, use and market bispecific antibody candidates based on the Company’s Biclonics^® technology platform against two undisclosed targets directed to a particular undisclosed target combination.

Under the terms of the agreement, ONO identifies and selects the licensed bispecific antibodies for which it is responsible for conducting further non-clinical and clinical development activities for such licensed bispecific antibodies and pharmaceutical products containing such antibodies, including manufacture and process development. Additionally, ONO controls and has exclusive rights over the worldwide commercialization of any approved products, including worldwide supply, and is solely responsible for all costs and expenses related to commercialization. ONO has also agreed to fund the Company’s research and development activities and be responsible for the payment of all costs and expenses for its own research and development activities, which are set out in a mutually agreed upon research plan. The Company retains all rights to use and commercialize any antibodies that are generated under the collaborative research program, excluding the up to five lead and/or selected antibodies against the targets ONO is pursuing, provided that the use and commercialization is not with respect to the particular target combination.

ONO agreed to pay the Company an upfront non-refundable payment of €0.7 million, €0.3 million intended to compensate the Company for research services already completed upon entering into the agreement, and €0.2 million to be paid to the Company over time for full time equivalent funding. The Company identified a single performance obligation of providing research services to ONO and recognized as revenue approximately €0.1 million and €1.1 million during the three and six months ended June 30, 2018, respectively.

Shareholders' Equity

6 Months Ended

Jun. 30, 2018

Shareholders' Equity

9.	Shareholders’ Equity

Private Placement of Common Shares

On February 13, 2018, the Company entered into the Purchase Agreement. Pursuant to the Purchase Agreement, the Company agreed to sell an aggregate of 3,099,997 of its Common Shares to the Investors for aggregate gross proceeds of approximately $55.8 million, at a purchase price equal to $18.00 per share. The Purchase Agreement contains customary representations and warranties from the Company and the Investors and customary closing conditions. On February 15, 2018, the Company completed the sale under the Private Placement and received gross proceeds of approximately $55.8 million, or €44.8 million.

Share Subscription Agreement with Incyte

Concurrent with the Incyte collaboration and license agreement discussed above under Note 8, the Company entered into a share subscription agreement with Incyte on December 20, 2016. On January 23, 2017, under the terms of the share subscription agreement, the Company issued 3,200,000 of its Common Shares to Incyte at the agreed price per share of $25.00, for an aggregate purchase price of $80.0 million or €74.7 million. During the six months ended June 30, 2017, the Company received proceeds, net of issuance costs, of €74.4 million. A €1.1 million discount on the subscription share price, combined with a €0.4 million foreign currency translation accompanying the issuance of these shares, increased share capital by €0.3 million and share premium by €73.4 million.

Issued and paid-in share capital

All issued shares have been fully paid in cash.

Common shares

For the six-month period ended June 30, 2018, 34,041 options were exercised at a weighted average exercise price of €1.93 per share. As a result, 34,041 Common Shares were issued, share capital increased by €3,064 and share premium increased by €62,635.

For the six-month period ended June 30, 2017, 110,869 options were exercised with a weighted average exercise price of €2.05 per share. As a result, 110,869 Common Shares were issued, share capital increased by €9,978 and share premium increased by €216,830.

At June 30, 2018, a total of 22,632,800 Common Shares were issued and paid up. At June 30, 2017, a total of 19,396,720 Common Shares were issued and paid up.

Share Premium Reserve

The share premium reserve relates to amounts contributed by shareholders at the issue of shares in excess of the nominal value of the shares issued.

All share premium can be considered as free share premium as referred to in the Netherlands Income Tax Act.

Share-based Payment Arrangements

Share-based payment expenses included in personnel expenses were €4.6 million and €7.9 million in the six-month periods ended June 30, 2018, and June 30, 2017, respectively. For details on the related share-based payment expenses recognized as employee benefit expenses, see Note 12.

In June 2016, the Company established the 2016 Incentive Award Plan (the “2016 Plan”). Options granted under the 2016 Plan are exercisable once vested. The options granted under the 2016 Plan vest in installments over a four-year period from the grant date. Twenty-five percent of the options vest on the first anniversary of the vesting commencement date, and the remaining 75% of the options vest in 36 monthly installments for each full month of continuous service provided by the option holder thereafter, such that 100% of the options shall become vested on the fourth anniversary of the vesting commencement date. Options will lapse on the tenth anniversary of the date of grant.

The Restricted Stock Units (“RSUs”) granted under the 2016 Plan also vest in installments over a four-year period from the grant date. Each RSU represents the right to receive one Common Share.

As stated in the 2016 Plan, the Company has established the Non-Executive Director Compensation Program whereas Non-Executive Directors are entitled to cash compensation as well as equity compensation. The equity compensation consists of an initial option grant as well as annual awards. The initial awards granted under the Non-Executive Director Compensation Program vest in installments over a three-year period. Thirty-three percent of the options vest on the first anniversary of the vesting commencement date, and the remaining 67% of the options in 24 substantially equal monthly installments thereafter, such that the award shall be fully vested on the third anniversary of the vesting commencement date. Each subsequent award shall vest and become exercisable in 12 substantially equal monthly installments following the vesting commencement date, such that the subsequent award shall be fully vested on the first anniversary of the date of grant.

Share-based payment expenses are recognized for each subsequent award that a Non-Executive Director is entitled to over their remaining term. Since subsequent awards are not subject to shareholder approval, the grant date is established and expenses are based on grant date fair value. The grant date fair value is not updated in each future reporting period and therefore the estimated fair value is not revised and expense recognized is based on the actual grant date fair value of the awards granted.

During the six months ended June 30, 2018, the Company granted options to purchase 469,068 Common Shares with a grant date fair value of €4.4 million to employees under the 2016 Plan.

Pursuant to the “evergreen” provisions of the 2016 Plan, the number of Common Shares authorized for issuance under the plan automatically increased by 777,194 Common Shares to 1,090,368 Common Shares effective January 1, 2018.

Measurement of fair values of the equity-settled share-based payment arrangements

The fair value of the employee share options has been measured using a binomial option pricing model, including members of the Board of Directors. Service and non-market performance conditions attached to the transactions were not taken into account in measuring fair value. Key management personnel include the Company’s executive management and the Board of Directors.

The inputs used in the measurement of the fair values and the related fair values at the grant dates were as follows for the options granted during the six-month period ended June 30, 2018:


	Key Management Personnel (€)	All Other Personnel (€)
Fair value at grant date	9.34-9.45	9.30-10.37
Share price at grant date	14.57-14.87	14.57-18.24
Exercise price	14.57-14.87	14.57-18.24
Expected volatility (weighted-average)	95.1%	94.6%
Contractual life	10 years	10 years
Expected dividends	0%	0%
Risk-free interest rate (based on government bonds)	2.79%-2.94%	2.84%-2.94%

Reconciliation of outstanding share options

The number of share options and the weighted average exercise prices of share options granted were as follows for the six-month period ended June 30, 2018:


	Weighted average exercise price (€)		Number of options
Outstanding at January 1, 2018		13.99		2,213,985
Forfeited during the six-month period		19.67		(12,044	)
Expired during the six-month period		14.02		(5,146	)
Exercised during the six-month period		1.93		(34,041	)
Granted during the six-month period		14.68		469,068

Outstanding at June 30, 2018		14.24		2,631,822
Exercisable at June 30, 2018		12.18		1,105,059

The options outstanding at June 30, 2018, had an exercise price in the range of €1.93 to €27.47 and a weighted-average remaining contractual life of 8.2 years. The weighted-average share price at the date of exercise for share options exercised during the six months ended June 30, 2018 was €17.12.

There were 2,631,822 outstanding share options at June 30, 2018, with a weighted average exercise price of €14.24.

The number of options outstanding as of June 30, 2018, was as follows:


Group of employees entitled	June 30, 2018
Key management personnel		2,153,810
All other employees		478,012

Total		2,631,822

During the six months ended June 30, 2018, the Company did not grant any new RSUs. The number of RSUs outstanding is summarized as follows:


	Weighted average grant price (€)		Number of RSU’s
Outstanding at January 1, 2018		20.03		194,546
Forfeited during the six-month period		—		—
Vested during the six-month period		20.03		(76,245	)
Granted during the six-month period		—		—

Outstanding at June 30, 2018		20.03		118,301

Revenue

6 Months Ended

Jun. 30, 2018

10.

Revenue

Revenue is recognized at the amount to which the Company expects to be entitled for the transfer of promised goods or services to customers.

Disaggregation of Revenue

The Company’s revenues are generated entirely in the Netherlands. In the following table, revenue is disaggregated by primary source of revenue as follows:

Three months ended

Six months ended

June 30,
2018

June 30,
2017 Restated*

June 30,
2018

June 30
2017 Restated*

(euros in thousands)

Upfront payment amortization

4,250

3,973

9,087

6,898

Collaboration income

2,179

1,471

7,195

2,391

Revenue from contracts with customers

6,429

5,444

16,282

9,289

Income from grants on research projects

114

793

182

832

6,543

6,237

16,464

10,121

*	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

For the three- and six-month periods ended June 30, 2018, the Company recognized amortization of €4.0 million and €7.9 million on upfront payments related to the Incyte collaboration and license agreement, respectively, amortization of €0.2 million and €1.1 million on upfront payments related to the ONO research and license agreement, respectively, and €0.1 million and €0.1 million on upfront payments related to the Simcere collaboration and license agreement, respectively. For the three- and six-month periods ended June 30, 2017, the Company recognized €4.0 million and €6.9 million of amortization of the upfront payment related to the Incyte collaboration and license agreement, respectively.

Collaboration income for the three and six months ended June 30, 2018, was €2.2 million and €7.2 million, respectively, and consisted of cost reimbursements and research milestones achieved in support of the Company’s research and license agreements with Incyte, ONO and Simcere. During the three and six months ended June 30, 2018, the Company recognized €2.0 million and €4.3 million of cost reimbursements in support of the Company’s research and license agreements with Incyte, respectively, and €0.1 million and €0.2 million of cost reimbursements in support of the Company’s research and license agreements with ONO, respectively.

The Company recognized an aggregate of €2.5 million in research milestones under its ONO agreements for the six months ended June 30, 2018 and €0.1 million in research milestones under its Simcere agreements for the three and six months ended June 30, 2018. During the three and six months ended June 30, 2017, the Company recognized €1.5 million and €2.4 million of cost reimbursements in support of the Company’s research and license agreements with Incyte and ONO, respectively.

The Company has been awarded grants consisting of cash allowances for specific research and development projects. The unconditional receipt of the grant allowances is dependent on the final review of the reporting provided by the Company at the end of the contract term. For the three and six months ended June 30, 2018, the Company recognized €0.1 million and €0.2 million in grant income, respectively, compared to €0.8 million in grant income for the three and six months ended June 30, 2017. On June 12, 2017, the European Commission approved for reimbursement the final installment of the FP-7 grant for €0.7 million. Revenue for this final installment was recorded in income from grants on research projects during the three and six months ended June 30, 2017.

Contract Balances

A trade receivable is recorded when the Company satisfies a performance obligation by transferring a promised good or service and has earned the unconditional right to consideration from its customer. Trade receivables relate to invoicing for cost reimbursements and research milestones achieved in support of the Company’s research and license agreements with Incyte, ONO and Simcere. Payment terms relating to these receivables are 30 days.

A contract asset is recorded when the Company satisfies a performance obligation by transferring a promised good or service and has earned the right to consideration from its customer. These assets represent a conditional right to consideration. Contract assets relate to unbilled amounts for cost reimbursements and research milestones achieved in support of the Company’s research and license agreements with Incyte and ONO.

A contract liability is recorded when consideration is received, or such consideration is unconditionally due, from a customer prior to transferring goods or services under the terms of the contract. Contract liabilities are recognized as revenue as control of the products or services is transferred to the customer and all revenue recognition criteria have been met. Contract liabilities relate to upfront payments received related to the Incyte Agreements, ONO research and license agreement, and the Simcere research and license agreement (See Note 8).

The following table presents changes in the Company’s trade receivables, contract assets and contract liabilities during the six months ended June 30, 2018:


	Balance at December 31, 2017 Restated		Additions		Deductions			Balance at June 30, 2018
	(euros in thousands)
Trade & other receivables
Trade receivables		1,594		12,103		(11,628	)		2,069

Total trade & other receivables		1,594		12,103		(11,628	)		2,069

Contract assets
Unbilled receivables		710		693		(957	)		446

Total contract assets		710		693		(957	)		446

Contract liabilities
Deferred revenue		128,486		3,430		(9,226	)		122,690

Total contract liabilities		128,486		3,430		(9,226	)		122,690

As a result of the adoption of IFRS 15, total deferred revenue was reduced by €8.7 million as of December 31, 2017. See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Deductions from deferred revenue are comprised of revenue recognized that was included in deferred revenue at the beginning of the period totaling €7.9 million and revenue recognized that was not included in deferred revenue at the beginning of the period totaling €1.3 million for the six months ended June 30, 2018.

Total Operating Expenses

6 Months Ended

Jun. 30, 2018

Total Operating Expenses

11.

Total Operating Expenses

Research and development costs are comprised of allocated employee costs, the costs of materials and laboratory consumables, intellectual property and license costs and allocated other costs.

A breakdown of total operating expenses is presented as follows:

Three-month period ended

June 30,

Six-month period ended

June 30,

2018

2017

2018

2017

(euros in thousands)

Manufacturing costs

5,580

2,236

9,858

5,611

IP and license costs

492

603

844

968

Personnel related R&D

2,107

1,771

3,808

3,303

Other research and development costs

4,344

3,810

8,311

5,545

Total research and development costs

12,523

8,420

22,821

15,427

Management and administration costs

2,639

3,492

5,491

7,694

Litigation costs

552

104

849

394

Other operating expenses

2,745

2,173

5,134

3,726

Total other expenses

3,297

2,277

5,983

4,120

Total operating expenses

18,459

14,189

34,295

27,241

Research and development costs were €12.5 million and €22.8 million for the three and six months ended June 30, 2018, respectively, as compared to €8.4 million and €15.4 million for the three- and six-month periods ended June 30, 2017, respectively. The increase in research and development costs is primarily attributable to the increase in manufacturing costs, higher research and development headcount and related costs, as well as additional spending in support of the Company’s clinical development programs for MCLA-128, MCLA-117, MCLA-158 and MCLA-145.The significant increase in manufacturing costs and other research and development costs during 2018 relate primarily to the expansion of the Company’s Phase 1 and Phase 1/2 clinical programs. Specifically, the Company incurred higher costs relating to outsourced contract manufacturing for process development and drug delivery in support of the Company’s MCLA-128 and MCLA-158 clinical development programs.

A breakdown of other research and development costs is presented as follows:

Three-month period ended

June 30,

Six-month period ended

June 30,

2018

2017

2018

2017

(euros in thousands)

Discovery and pre-clinical costs

1,078

1,698

1,763

2,076

Clinical costs

1,850

1,292

4,248

2,002

Other research and development costs

1,416

820

2,300

1,467

Total other research and development costs

4,344

3,810

8,311

5,545

Other research and development costs consist mainly of laboratory supplies and depreciation expense related to research and development activities, which cannot be specifically allocated to a research project.

Litigation costs

On March 11, 2014, Regeneron Pharmaceuticals, Inc. (“Regeneron”) filed a complaint in the United States District Court for the Southern District of New York (the “Court”), alleging that the Company was infringing on one or more claims in Regeneron’s U.S. Patent No. 8,502,018, entitled “Methods of Modifying Eukaryotic Cells” (the “018 Patent”). On July 3, 2014, the Company filed a response to the complaint, denying Regeneron’s allegations of infringement and raising affirmative defenses, and filed counterclaims seeking, among other things, a declaratory judgment that the Company did not infringe the patent and that the patent was invalid. The Company subsequently filed amended counterclaims during the period from August to December 2014, seeking a declaratory judgment of unenforceability of the patent due to Regeneron’s commission of inequitable conduct.

On November 21, 2014, the Court found that there was clear and convincing evidence that a claim term present in each of the patent claims was indefinite and granted the Company’s proposed claim constructions. On February 24, 2015, the Court entered partial judgment in the proceeding, on the grounds that the Company did not infringe each of the patent claims, and that each of the patent claims were invalid due to indefiniteness. On November 2, 2015, the Court found Regeneron had withheld material information from the United States Patent and Trademark Office during prosecution of the patent, and Regeneron had engaged in inequitable conduct and affirmative egregious misconduct in connection with the prosecution of the patent. On December 18, 2015, Regeneron filed an appeal of the Court’s decision. On July 27, 2017, the U.S. Court of Appeals for the Federal Circuit affirmed the trial court’s conclusion that Regeneron had engaged in inequitable conduct before the United States Patent and Trademark Office and affirmed that the ‘018 patent is unenforceable. Regeneron petitioned for a panel rehearing and rehearing en banc of this decision by the Federal Circuit on September 12, 2017, which the Company responded to and opposed on November 2, 2017. On December 26, 2017, the full Federal Circuit denied Regeneron’s request to rehear the matter.

The case returned to the District Court to adjudicate the Company’s motion requesting that Regeneron pay the Company’s attorneys’ fees and costs incurred as a result of Regeneron filing suit. On March 26, 2018, the trial court granted the Company’s motion for attorneys’ fees, expert fees, and costs and ordered the parties to address the amount of award. The Company provided a detailed explanation of its attorneys’ fees, expert fees, and costs of such award, which Regeneron responded to seeking a reduction of the amount. The matter was fully briefed as of May 18, 2018, and the Court issued an Order on June 25, 2018, which published on July 10, 2018, granting the Company’s motion for $8,332,453.46 in attorneys’ fees, $465,390.34 in expert fees, and $1,717,100.69 in litigation expenses and costs, along with interest. Regeneron has appealed the decision awarding attorneys’ fees to the Company to the Federal Circuit. On May 25, 2018, Regeneron filed a petition for writ of certiorari seeking review by the Supreme Court of the United States of the decision affirmed by the Federal Circuit. The Company’s brief in opposition was filed on August 8, 2018.

On March 11, 2014, Regeneron served a writ in the Netherlands alleging that the Company was infringing one or more claims of the European patent EP 1 360 287 B1. The Company opposed the patent in June 2014. On September 17, 2014, Regeneron’s patent EP 1 360 287 B1 was revoked in its entirety by the European Opposition Division of the European Patent Office (the “EPO”). In Europe, an appeal hearing occurred in October and November 2015 at the Technical Board of Appeal for the EPO at which time the patent was reinstated to Regeneron with amended claims. On May 25, 2018, at Regeneron’s request, a hearing before the Technical Board of Appeals for the EPO was scheduled for September 13, 2018, to address whether the description of EP 1 360 287 B1 patent having claims amended during the course of opposition complies with Art. 84 EPC, Art. 123(2) EPC and Rule 80 EPC. The Company believes that its current business operations do not infringe the patent reinstated to Regeneron with amended claims because it believes it has not used the technology or methods claimed under the amended claims. The Dutch litigation procedure is stayed.

The costs incurred in the above litigation and opposition were €0.6 million and €0.8 million for the three- and six-month periods ended June 30, 2018, respectively, as compared to €0.1 million and €0.4 million for the three- and six-month periods ended June 30, 2017, respectively, and are included in the statement of profit or loss and comprehensive loss for the period.

On July 15, 2014, Regeneron filed a notice of opposition against the Company’s EP 2314629 patent (the “EP ’629 patent”), entitled “Recombinant Production of Mixtures of Antibodies,” in the EPO. The notice asserted, as applicable, added subject matter, lack of novelty, lack of inventive step, and insufficiency. The Company responded on February 24, 2015. Following an oral hearing before the Opposition Division of the EPO on June 22, 2016, the Opposition Division upheld the EP ’629 Patent with amendments. Both Regeneron and the Company filed a notice of appeal followed by grounds of appeal on December 1 and 4, 2017, respectively, with further proceedings to follow.

On August 11, 2014, Regeneron filed a notice of opposition against the Company’s EP 2147594 (the “EP ’594 patent”), entitled “Antibody Producing Non-Human Mammals,” in the EPO. The notice asserted, as applicable, lack of novelty, lack of inventive step, and insufficiency. The Company’s response to the oppositions was filed on April 2, 2015. Following an oral hearing before the Opposition Division of the EPO on October 28, 2016, the Opposition Division upheld the EP ’594 Patent without amendments. Regeneron filed grounds of appeal on July 19, 2017, and the Company responded on November 30, 2017.

On April 5, 2018, Regeneron and an unnamed third party filed notices of opposition against the Company’s EP 2604625 patent (the “EP ‘625 patent”), entitled “Generation of Binding Molecules,” in the EPO. The notices asserted, as applicable, added subject matter, lack of novelty, lack of inventive step, and insufficiency. The Company intends to timely respond to these submissions with proceedings to be ongoing.

As each of these proceedings continues, the Company is not able to predict the outcome of, or estimate a possible gain or a range of possible loss, if any, related to the above actions. Based on the current facts and circumstances, no provision has been recognized under IAS 37 related to contingent liabilities.

Employee Benefits

6 Months Ended

Jun. 30, 2018

Employee Benefits

12.

Employee Benefits

Details of the employee benefits are as follows:


	Three-month period ended June 30,						Six-month period ended June 30,
	2018			2017			2018			2017
	(euros in thousands)
Salaries and wages		2,876			2,451			5,505			4,182
WBSO subsidy		(733	)		(953	)		(1,900	)		(2,005	)
Social security premiums		198			146			449			293
Health insurance		69			36			188			62
Pension costs		188			181			390			322
Share award expense		2,109			3,254			4,554			7,880
Other personnel expense		224			148			433			264

Total employee benefits expense		4,931			5,263			9,619			10,998

Share-based payment expenses (see Note 9) were recognized as employee benefit expenses as follows:


	Three-month period ended June 30,				Six-month period ended June 30,
	2018		2017		2018		2017
	(euros in thousands)
Research and development costs		714		673		1,525		1,798
Management and administrative costs		1,343		2,376		2,852		5,782
Other expenses		52		205		177		300

		2,109		3,254		4,554		7,880

Subsidies earned under the WBSO relating to eligible research and development costs are deferred and recognized in the Company’s income statement as a reduction to labor costs over the period labor costs are expected to be incurred. The Company has received and recognized subsidies of €0.7 million and €1.9 million for the three- and six-monthperiods ended June 30, 2018, respectively, as compared to €1.0 million and €2.0 million for the three- and six-month periods ended June 30, 2017, respectively. The decrease in subsidies is primarily attributable to the decrease in eligible payroll tax withholdings during the same period.

The Company’s headcount at June 30, 2018 was approximately 85 full-time equivalents and consisted of 70 employees in the Netherlands and 15 employees in the United States. A total of 18 employees who are devoted to activities other than research and development and overall management of the Company were included under management and administration costs for the three- and six-month periods ended June 30, 2018.

The Company’s headcount at June 30, 2017 was approximately 64 full-time equivalents and consisted of 55 employees in the Netherlands and nine employees in the United States. A total of 13 employees who were devoted to activities other than research and development and overall management of the Company were included under management and administration costs for the three- and six-month periods ended June 30, 2017.

Finance Income and Expense

6 Months Ended

Jun. 30, 2018

Finance Income and Expense

13.

Finance Income and Expense


	Three-month period ended June 30,						Six-month period ended June 30,
	2018			2017			2018			2017
	(euros in thousands)
Finance income
Interest income and similar income		494			420			834			610
Net gain on foreign exchange		6,917			—			4,111			—

		7,411			420			4,945			610

Finance costs
Interest expense		(1	)		—			(1	)		(10,667	)
Net loss on foreign exchange		—			(11,962	)		—			(12,029	)

		(1	)		(11,962	)		(1	)		(22,696	)

Interest income primarily results from interest earned on cash held on account and accretion of investment earnings. The Company’s current year increase in cash, cash equivalents and investments was due primarily to the $55.8 million of funds received as part of the Private Placement during the first quarter of 2018.

The Company experienced gains on its U.S. dollar denominated cash, cash equivalents and investments of approximately €6.9 million and €4.1 million for the three and six months ended June 30, 2018, respectively, as compared to losses of €12.0 million for the three and six months ended June 30, 2017. The Company presents foreign currency gains and losses on a net basis as either finance income or finance expense depending on whether foreign currency movements are in a net gain or net loss position. The Company experienced foreign exchange losses on its U.S. dollar denominated cash, cash equivalents and investments of approximately €2.8 million during the three months ended March 31, 2018, which are reclassified to net gain on foreign exchange for the six months ended June 30, 2018. As of June 30, 2018, the Company held approximately $40.9 million and $92.6 million in U.S. dollar denominated cash and cash equivalent accounts and investment accounts, respectively, subject to the fluctuation in foreign currency between the euro and U.S. dollar.

On December 20, 2016, the Company entered into the Incyte Agreements. As these contracts are denominated in U.S. dollars, the Company determined that the subscription agreement to sell its own shares to which the Company became committed on December 20, 2016, should be accounted for as a forward contract or a derivative financial instrument. Interest expense for the three and six months ended June 30, 2017, related entirely to the effective settlement of the forward contract on January 23, 2017.

Operating Leases

6 Months Ended

Jun. 30, 2018

Operating Leases

14.

Operating Leases

The Company leases its corporate headquarters under an agreement term of five years which expires in the fourth quarter of 2021. If the lease is not terminated by Merus N.V. it will be automatically renewed for a period of two years. The agreed rental price is €0.4 million per year. On May 1, 2018, the Company leased additional space to expand its corporate headquarters under a separate agreement. Under the terms of the new agreement, the term began on May 1, 2018, and expires in the fourth quarter of 2021. The agreed upon rental price is €0.5 million per year.

For leases that contain fixed increases in the minimum annual lease payment during the original term of the lease, the Company recognizes rental expense on a straight-line basis over the lease term and records the difference between rent expense and the amount currently payable as deferred rent as a component of other liabilities and accruals. For the three and six months ended June 30, 2018, the Company recognized €0.3 million and €0.5 million, respectively, compared to €0.2 million and €0.3 million for the three and six months ended June 30, 2017, respectively, for rent and service charges related to the office space. In addition, the Company has provided a deposit of €0.1 million included in other assets as of June 30, 2018, and December 31, 2017.

Subsequent Events

6 Months Ended

Jun. 30, 2018

Subsequent Events

15.

Subsequent Events

The Company has evaluated subsequent events through August 10, 2018, the date of issuance of the unaudited consolidated financial statements for the three months ended June 30, 2018.

Except for the items described in Note 11 under litigation, there were no additional events requiring disclosure in the notes to these financial statements.

Significant accounting policies (Policies)	6 Months Ended
Significant accounting policies (Policies)	Jun. 30, 2018
Text block [abstract]
Basis of Presentation	Basis of Presentation These unaudited interim condensed consolidated financial statements (the “interim financial statements”) have been prepared in accordance with International Accounting Standard 34 “Interim Financial Reporting” as issued by the International Accounting Standards Board (“IASB”). Certain information and disclosures normally included in financial statements prepared in accordance with International Financial Reporting Standards (“IFRS”) have been condensed or omitted. Accordingly, these interim financial statements should be read in conjunction with the Company’s annual financial statements for the year ended December 31, 2017. In the opinion of management, all adjustments (consisting of a normal recurring nature) considered necessary for a fair presentation have been included in the interim financial statements. All intercompany transactions and balances are eliminated in consolidation.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with IFRS requires the use of certain critical accounting estimates. It also requires management to exercise its judgment in the process of applying the Company’s accounting policies. The areas involving a higher degree of judgment or complexity or areas where assumptions and estimates are significant to these interim financial statements are disclosed in Note 4. The results of operations for the three- and six-month periods ended June 30, 2018, are not necessarily indicative of operations to be expected for the full fiscal year ending December 31, 2018.
Foreign Currency Transactions	Foreign Currency Transactions Items recorded in each of the Company’s entities are measured using the currency of the primary economic environment in which the entity operates (the “functional currency”). The interim financial statements are presented in euros, which is Merus N.V.’s functional currency. The functional currency of Merus US, Inc. is the U.S. dollar. All amounts are rounded to the nearest thousand euros, except where otherwise indicated. Foreign currency gains and losses are reported on a net basis as either finance income or finance expense depending on whether foreign currency movements are in a net gain or net loss position.
Seasonality	Seasonality The Company’s financial results have varied substantially, and are expected to continue to vary, from period to period. The Company believes that its ordinary activities are not linked to any particular seasonal factors.
Segment Reporting	Segment Reporting The Company operates in one reportable segment, which comprises the discovery and development of innovative bispecific therapeutics.
Cash and Cash Equivalents	Cash and Cash Equivalents For the purpose of presentation in the statement of cash flows as well as the statement of financial position, cash and cash equivalents include deposits held with financial institutions with original maturities of less than three months. Cash and cash equivalents include €34.3 million of short-term investments with a three-month or less maturity, callable on demand. The carrying values of short-term investments approximate fair value due to their short-term maturities.
Revenue Recognition	Revenue Recognition The Company enters into collaboration agreements which are within the scope of IFRS 15—Revenue from Contracts with Customers (“IFRS 15”), under which the Company licenses rights to certain of the Company’s product candidates and performs research and development services. The terms of these arrangements typically include payment of one or more of the following: non-refundable, upfront fees; reimbursement of research and development costs; development, regulatory, and commercial milestone payments; and royalties on net sales of licensed products. IFRS 15 requires an entity to recognize the amount of revenue to which it expects to be entitled for the transfer of promised goods or services to customers. Under IFRS 15, the Company recognizes revenue when its customer obtains control of the goods or services, in an amount that reflects the consideration that the Company determines it expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of IFRS 15, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies the performance obligation. The Company applies the five-step model to contracts only when it is probable that it will collect the consideration to which it is entitled in exchange for the goods or services it transfers to the customer. As part of the accounting for these arrangements, the Company must make significant judgments, including identifying performance obligations in the contract, estimating the amount of variable consideration to include in the transaction price and allocating the transaction price to each performance obligation. The Company currently generates a portion of its revenue through collaboration and license agreements with strategic collaborators for the development and commercialization of product candidates. The collaboration and license agreements are within the scope of IFRS 15. Up-front License Payments If the license to the Company’s intellectual property is determined to be distinct from the other performance obligations identified in the agreement, the Company recognizes revenues from non-refundable, up-front fees allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license. If not distinct, the license is combined with other performance obligations in the contract. For licenses that are combined with other performance obligations, the Company assesses the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purpose of recognizing revenue. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. Pursuant to the Company’s research and license agreements with its collaborators, the Company has received upfront license payments relating to the integrated packages of deliverables under the contracts. Each contract contains either one single performance obligation or multiple performance obligations that the up-front consideration was allocated to. These upfront license payments are initially recorded in deferred revenue on the consolidated statements of financial position and are recognized as revenue on either: (i) a straight-line basis over the period of the related performance obligation or the contractual term of the arrangement; or (ii) based on another appropriate depiction of the Company’s performance over the period of the related performance obligation or the contractual term, such as costs incurred relating to full-time equivalent research employees. The applicable period over which to recognize the upfront payment is a significant judgment, which is re-assessed at each reporting date. Collaboration Income Collaboration income, which is typically related to reimbursements from collaborators for the Company’s performance of research and development services under the respective agreements, is recognized on the basis of labor hours valued at a contractually agreed rate. Collaboration income includes reimbursements for related out-of-pocket expenses. Cost reimbursements to which the Company is entitled under agreements are recognized as revenue in the same period as the cost for which they are intended to compensate. The Company acts as the principal and therefore records these reimbursements as collaboration income. In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under the agreements, the Company performs the five steps listed above. As part of the accounting for the arrangement, the Company must develop assumptions that require judgment to determine the stand-alone selling price for each performance obligation identified in the contract. The Company uses key assumptions to determine the stand-alone selling price, which may include market conditions, reimbursement rates for personnel costs, development timelines and probabilities of regulatory success. The Company capitalizes the incremental costs of obtaining a contract with a customer if it expects to recover those costs. Such incremental costs would not have been incurred if the contract with a customer had not been obtained. To date, the Company has not capitalized any incremental costs for obtaining a contract. The Company’s contracts often include development and regulatory milestone payments which are assessed under the most likely amount method and constrained if it is probable that a significant revenue reversal would occur. Milestone payments that are not within the Company’s control or the licensee’s control, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. At each reporting date, the Company re-evaluates the probability of achievement of development milestones and any related constraint, and if necessary, adjusts the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect collaboration revenues in the period of adjustment. For agreements that include sales-based royalties, including milestone payments based on the level of sales, and the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). To date, the Company has not recognized any consideration related to sales-based royalty revenue resulting from any of the Company’s collaboration agreements. Government Grants The Company receives certain government and regional grants, which support its research efforts in defined projects, and include contributions towards the cost of research and development. When there is reasonable assurance that the Company will comply with the conditions attached to a received grant, and when there is reasonable assurance that the grant will be received, government grants are recognized as revenue on a gross basis in the consolidated statement of profit or loss and comprehensive loss on a systematic basis over the periods in which the Company recognizes expenses for the related costs for which the grants are intended to compensate. In the case of grants related to assets, the received grant will be deducted from the carrying amount of the asset.
Reclassifications	Reclassifications Certain amounts were reclassified in the prior period condensed consolidated interim financial statements to conform to the current period presentation.

Recently Issued International Financial Reporting Standards (Tables)

6 Months Ended

Jun. 30, 2018

Condensed Consolidated Statements of Financial Information

Condensed Consolidated Statement of Profit or Loss and Comprehensive Loss


	Three months ended June 30, 2017 (As originally presented)			IFRS 15 Adoption		Three months ended June 30, 2017 Restated
	(euros in thousands)
Revenue		4,027			2,210		6,237
Operating result		(10,162	)		2,210		(7,952	)
Total comprehensive loss for the period		(21,798	)		2,210		(19,588	)
Basic (and diluted) loss per share		(1.12	)		0.11		(1.01	)


	Six months ended June 30, 2017 (As originally presented)			IFRS 15 Adoption		Six months ended June 30, 2017 Restated
	(euros in thousands)
Revenue		6,313			3,808		10,121
Operating result		(20,928	)		3,808		(17,120	)
Total comprehensive loss for the period		(43,114	)		3,808		(39,306	)
Basic (and diluted) loss per share		(2.27	)		0.20		(2.07	)

Condensed Consolidated Statement of Financial Position


	December 31, 2017 As originally presented			IFRS 15 Adoption			December 31, 2017 Restated
	(euros in thousands)
Accumulated loss		(167,480	)		8,705			(158,775	)
Deferred revenue, non-current		130,195			(17,644	)		112,551
Deferred revenue		6,996			8,939			15,935

Condensed Consolidated Statement of Cash Flows


	June 30, 2017 As originally presented			IFRS 15 Adoption			June 30, 2017 Restated
	(euros in thousands)
Result after taxation		(43,132	)		3,808			(39,324	)
Changes in working capital:
Deferred revenue		(3,091	)		(3,808	)		(6,899	)

Investments (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Investments

Investments as of June 30, 2018, and December 31, 2017, consist of the following:


	Balance as per
	June 30, 2018		December 31, 2017
	(euros in thousands)
Commercial paper		17,715		15,527
U.S. Treasury securities		2,574		9,177
Corporate fixed income bonds		15,289		7,886
Agency bond		1,499		1,453

Investments, current portion		37,077		34,043
Corporate fixed income bonds		16,650		7,060

Non-current investments		16,650		7,060

Total investments		53,727		41,103

Trade and Other Receivables (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Trade and Other Receivables Due Within 1 Year

Trade and other receivables are short-term and due within 1 year.


	Balance as per
	June 30, 2018		December 31, 2017
	(euros in thousands)
Trade receivables		2,069		1,594
Unbilled receivables		446		710
VAT receivable		622		582
Prepaid expenses		1,640		427
Prepaid pension costs		359		838
Interest bank		275		170
Other receivables		66		92

		5,477		4,413

Other Liabilities and Accruals (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Short-term and Payable Within 1 Year

All amounts are short-term and payable within 1 year.


	Balance per
	June 30, 2018		December 31, 2017
	(euros in thousands)
Accrued auditor’s fee		90		96
Personnel		315		446
R&D costs		8,777		5,272
IP – Legal fee		128		509
Bonuses		940		1,545
Subsidy advance received		145		224
Other accruals		465		535

		10,860		8,627

Deferred Revenue (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Deferred Revenue

Deferred revenue as of June 30, 2018, and December 31, 2017, consist of the following:


	Balance per
	June 30, 2018		December 31, 2017 Restated*
	(euros in thousands)
Deferred revenue – current portion		16,972		15,935
Deferred revenue		105,718		112,551

		122,690		128,486

*	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Shareholders' Equity (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Inputs Used in the Measurement of the Fair Values and the Related Fair Values at the Grant Dates

The inputs used in the measurement of the fair values and the related fair values at the grant dates were as follows for the options granted during the six-month period ended June 30, 2018:


	Key Management Personnel (€)	All Other Personnel (€)
Fair value at grant date	9.34-9.45	9.30-10.37
Share price at grant date	14.57-14.87	14.57-18.24
Exercise price	14.57-14.87	14.57-18.24
Expected volatility (weighted-average)	95.1%	94.6%
Contractual life	10 years	10 years
Expected dividends	0%	0%
Risk-free interest rate (based on government bonds)	2.79%-2.94%	2.84%-2.94%

Summary of Reconciliation of Outstanding Share Options

The number of share options and the weighted average exercise prices of share options granted were as follows for the six-month period ended June 30, 2018:


	Weighted average exercise price (€)		Number of options
Outstanding at January 1, 2018		13.99		2,213,985
Forfeited during the six-month period		19.67		(12,044	)
Expired during the six-month period		14.02		(5,146	)
Exercised during the six-month period		1.93		(34,041	)
Granted during the six-month period		14.68		469,068

Outstanding at June 30, 2018		14.24		2,631,822
Exercisable at June 30, 2018		12.18		1,105,059

Summary of Number of Share Options Outstanding

The number of options outstanding as of June 30, 2018, was as follows:


Group of employees entitled	June 30, 2018
Key management personnel		2,153,810
All other employees		478,012

Total		2,631,822

Summary of Reconciliation of RSU's

During the six months ended June 30, 2018, the Company did not grant any new RSUs. The number of RSUs outstanding is summarized as follows:


	Weighted average grant price (€)		Number of RSU’s
Outstanding at January 1, 2018		20.03		194,546
Forfeited during the six-month period		—		—
Vested during the six-month period		20.03		(76,245	)
Granted during the six-month period		—		—

Outstanding at June 30, 2018		20.03		118,301

Revenue (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Changes in Tarde Receivables, Contract Assets and Contract Liabilities

Summary of Revenue

The Company’s revenues are generated entirely in the Netherlands. In the following table, revenue is disaggregated by primary source of revenue as follows:

Three months ended

Six months ended

June 30,
2018

June 30,
2017 Restated*

June 30,
2018

June 30
2017 Restated*

(euros in thousands)

Upfront payment amortization

4,250

3,973

9,087

6,898

Collaboration income

2,179

1,471

7,195

2,391

Revenue from contracts with customers

6,429

5,444

16,282

9,289

Income from grants on research projects

114

793

182

832

6,543

6,237

16,464

10,121

*	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

The following table presents changes in the Company’s trade receivables, contract assets and contract liabilities during the six months ended June 30, 2018:


	Balance at December 31, 2017 Restated		Additions		Deductions			Balance at June 30, 2018
	(euros in thousands)
Trade & other receivables
Trade receivables		1,594		12,103		(11,628	)		2,069

Total trade & other receivables		1,594		12,103		(11,628	)		2,069

Contract assets
Unbilled receivables		710		693		(957	)		446

Total contract assets		710		693		(957	)		446

Contract liabilities
Deferred revenue		128,486		3,430		(9,226	)		122,690

Total contract liabilities		128,486		3,430		(9,226	)		122,690

Total Operating Expenses (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Total Operating Expenses

A breakdown of total operating expenses is presented as follows:

Three-month period ended

June 30,

Six-month period ended

June 30,

2018

2017

2018

2017

(euros in thousands)

Manufacturing costs

5,580

2,236

9,858

5,611

IP and license costs

492

603

844

968

Personnel related R&D

2,107

1,771

3,808

3,303

Other research and development costs

4,344

3,810

8,311

5,545

Total research and development costs

12,523

8,420

22,821

15,427

Management and administration costs

2,639

3,492

5,491

7,694

Litigation costs

552

104

849

394

Other operating expenses

2,745

2,173

5,134

3,726

Total other expenses

3,297

2,277

5,983

4,120

Total operating expenses

18,459

14,189

34,295

27,241

Breakdown of Other Research and Development Costs

A breakdown of other research and development costs is presented as follows:

Three-month period ended

June 30,

Six-month period ended

June 30,

2018

2017

2018

2017

(euros in thousands)

Discovery and pre-clinical costs

1,078

1,698

1,763

2,076

Clinical costs

1,850

1,292

4,248

2,002

Other research and development costs

1,416

820

2,300

1,467

Total other research and development costs

4,344

3,810

8,311

5,545

Employee Benefits (Tables)

6 Months Ended

Jun. 30, 2018

Disclosure of Detailed Information About Employee Benefits

Details of the employee benefits are as follows:


	Three-month period ended June 30,						Six-month period ended June 30,
	2018			2017			2018			2017
	(euros in thousands)
Salaries and wages		2,876			2,451			5,505			4,182
WBSO subsidy		(733	)		(953	)		(1,900	)		(2,005	)
Social security premiums		198			146			449			293
Health insurance		69			36			188			62
Pension costs		188			181			390			322
Share award expense		2,109			3,254			4,554			7,880
Other personnel expense		224			148			433			264

Total employee benefits expense		4,931			5,263			9,619			10,998

Schedule of Share-based Compensation Expenses Recognized as Employee Benefit Expenses

Share-based payment expenses (see Note 9) were recognized as employee benefit expenses as follows:


	Three-month period ended June 30,				Six-month period ended June 30,
	2018		2017		2018		2017
	(euros in thousands)
Research and development costs		714		673		1,525		1,798
Management and administrative costs		1,343		2,376		2,852		5,782
Other expenses		52		205		177		300

		2,109		3,254		4,554		7,880

Finance Income and Expense (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Finance Income and Expense


	Three-month period ended June 30,						Six-month period ended June 30,
	2018			2017			2018			2017
	(euros in thousands)
Finance income
Interest income and similar income		494			420			834			610
Net gain on foreign exchange		6,917			—			4,111			—

		7,411			420			4,945			610

Finance costs
Interest expense		(1	)		—			(1	)		(10,667	)
Net loss on foreign exchange		—			(11,962	)		—			(12,029	)

		(1	)		(11,962	)		(1	)		(22,696	)

General Information - Additional Information (Detail)
€ / shares in Units, $ / shares in Units, € in Thousands, $ in Millions

1 Months Ended

6 Months Ended

Feb. 13, 2018

USD ($)

$ / shares

Feb. 28, 2018

EUR (€)

Feb. 28, 2018

USD ($)

Jan. 31, 2017

USD ($)

Jun. 30, 2018

EUR (€)

Jun. 30, 2017

EUR (€)

^[1]

Feb. 13, 2018

€ / shares

Dec. 31, 2017

EUR (€)

Dec. 31, 2016

EUR (€)

^[1]

Disclosure of general information [abstract]

Issue price per share | € / shares

3,099,997

€ 0.09

$ 55.8

€ 44,800

$ 55.8

$ 80.0

€ 44,731

€ 74,431

Cash and cash equivalents

$ 18.00

170,327

€ 215,788

€ 149,678

^[1]

€ 56,917

Investments

€ 53,727

€ 41,103

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Significant Accounting Policies - Additional Information (Detail) € in Millions	6 Months Ended
	Jun. 30, 2018 EUR (€) Segment
Disclosure of significant accounting policies [abstract]
Number of reportable segment \| Segment	1
Cash and cash equivalents, maximum original maturities	3 months
Short-term investments \| €	€ 34.3

Recently Issued International Financial Reporting Standards - Additional Information (Detail) - EUR (€) € in Millions		6 Months Ended	12 Months Ended
	Apr. 08, 2014	Jun. 30, 2018	Dec. 31, 2017
IFRS 15 revenue from contracts with customers [member]
Disclosure of changes in accounting estimates [line items]
Decrease in Deferred revenue		€ 8.7	€ 8.7
Incyte collaboration agreement [member]
Disclosure of changes in accounting estimates [line items]
Estimated contractual term		21 years
ONO Research and License Agreement [member]
Disclosure of changes in accounting estimates [line items]
Estimated contractual term	4 years 6 months
Incyte proprietary technology [member]
Disclosure of changes in accounting estimates [line items]
Estimated contractual term		9 years

Recently Issued International Financial Reporting Standards - Condensed Consolidated Statements of Profit or Loss and Comprehensive Loss (Detail) - EUR (€)
€ / shares in Units, € in Thousands

3 Months Ended

6 Months Ended

Jun. 30, 2018

Jun. 30, 2017

Jun. 30, 2018

Jun. 30, 2017

Condensed Income Statements, Captions [Line Items]

€ 6,543

€ 6,237

^[1]

€ 16,464

€ 10,121

^[1]

(11,916)

(7,952)

^[1]

(17,831)

(17,120)

^[1]

€ (4,557)

€ (19,588)

^[1]

€ (13,005)

€ (39,306)

^[1]

Previously stated [member]

^[2]

€ (0.20)

€ (1.01)

^[1]

€ (0.60)

€ (2.07)

^[1]

Condensed Income Statements, Captions [Line Items]

€ 4,027

€ 6,313

(10,162)

(20,928)

€ (21,798)

€ (43,114)

Increase (decrease) due to application of IFRS 15 [member]

€ (1.12)

€ (2.27)

Condensed Income Statements, Captions [Line Items]

€ 2,210

€ 3,808

2,210

3,808

€ 2,210

€ 3,808

€ 0.11

€ 0.20

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.
[2]	For the periods included in these financial statements, share options were excluded from the diluted loss per share calculation as the Company was in a loss position in each period presented above. As a result, basic and diluted loss per share is equal.

Condensed Balance Sheet Statements, Captions [Line Items]

The income arising in the course of an entity's ordinary activities. Income is increases in economic benefits during the accounting period in the form of inflows or enhancements of assets or decreases of liabilities that result in an increase in equity, other than those relating to contributions from equity participants.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 28
-Subparagraph a
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_28_a&doctype=Standard
-URIDate 2018-03-16

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 23
-Subparagraph a
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_23_a&doctype=Standard
-URIDate 2018-03-16

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 32
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_32&doctype=Standard
-URIDate 2018-03-16

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 33
-Subparagraph a
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_33_a&doctype=Standard
-URIDate 2018-03-16

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 34
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_34&doctype=Standard
-URIDate 2018-03-16

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Name IAS
-Number 1
-IssueDate 2018-01-01
-Paragraph 82
-Subparagraph a
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IAS&num=1&date=2018-03-01&anchor=para_82_a&doctype=Standard
-URIDate 2018-03-16

Reference 7: http://www.xbrl.org/2003/role/exampleRef
-Name IAS
-Number 1
-IssueDate 2018-01-01
-Paragraph 103
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IAS&num=1&date=2018-03-01&anchor=para_103&doctype=Standard
-URIDate 2018-03-16

Reference 8: http://www.xbrl.org/2003/role/exampleRef
-Name IAS
-Number 1
-IssueDate 2018-01-01
-Paragraph 102
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IAS&num=1&date=2018-03-01&anchor=para_102&doctype=Standard
-URIDate 2018-03-16

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 5
-IssueDate 2018-01-01
-Paragraph 33
-Subparagraph b
-Clause i
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=5&date=2018-03-01&anchor=para_33_b_i&doctype=Standard
-URIDate 2018-03-16

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 12
-IssueDate 2018-01-01
-Paragraph B12
-Subparagraph b
-Clause v
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=12&date=2018-03-01&anchor=para_B12_b_v&doctype=Appendix&seq=2
-URIDate 2018-03-16

Reference 11: http://www.xbrl.org/2003/role/exampleRef
-Name IFRS
-Number 12
-IssueDate 2018-01-01
-Paragraph B10
-Subparagraph b
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=12&date=2018-03-01&anchor=para_B10_b&doctype=Appendix&seq=2
-URIDate 2018-03-16

+ Details

Recently Issued International Financial Reporting Standards - Condensed Consolidated Statements of Financial Positions (Detail) - EUR (€)
€ in Thousands

Jun. 30, 2018

Dec. 31, 2017

Deferred revenue, non-current

€ (167,226)

€ (158,775)

^[1]

105,718

112,551

^[1]

Previously stated [member]

€ 16,972

15,935

^[1]

Condensed Balance Sheet Statements, Captions [Line Items]

Deferred revenue, non-current

(167,480)

130,195

Increase (decrease) due to application of IFRS 15 [member]

6,996

Condensed Balance Sheet Statements, Captions [Line Items]

Deferred revenue, non-current

8,705

(17,644)

Condensed Cash Flow Statements, Captions [Line Items]

€ 8,939

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Recently Issued International Financial Reporting Standards - Condensed Consolidated Statements of Cash Flows (Detail) - EUR (€)
€ in Thousands

3 Months Ended

6 Months Ended

Jun. 30, 2018

Jun. 30, 2017

^[1]

Jun. 30, 2018

Jun. 30, 2017

€ (4,593)

€ (19,601)

€ (13,026)

€ (39,324)

^[1]

Previously stated [member]

€ (5,796)

(6,899)

^[1]

Condensed Cash Flow Statements, Captions [Line Items]

(43,132)

Increase (decrease) due to application of IFRS 15 [member]

(3,091)

Condensed Cash Flow Statements, Captions [Line Items]

3,808

€ (3,808)

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Disclosure of changes in accounting estimates [line items]

The total of income less expenses from continuing and discontinued operations, excluding the components of other comprehensive income. [Refer: Other comprehensive income]

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Name IAS
-Number 7
-IssueDate 2018-01-01
-Paragraph 18
-Subparagraph b
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IAS&num=7&date=2018-03-01&anchor=para_18_b&doctype=Standard
-URIDate 2018-03-16

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 1
-IssueDate 2018-01-01
-Paragraph 24
-Subparagraph b
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=1&date=2018-03-01&anchor=para_24_b&doctype=Standard
-URIDate 2018-03-16

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 1
-IssueDate 2018-01-01
-Paragraph 32
-Subparagraph a
-Clause ii
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=1&date=2018-03-01&anchor=para_32_a_ii&doctype=Standard
-URIDate 2018-03-16

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 28
-Subparagraph b
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_28_b&doctype=Standard
-URIDate 2018-03-16

Reference 5: http://www.xbrl.org/2003/role/exampleRef
-Note Effective on first application of IFRS 9
-Name IFRS
-Number 4
-IssueDate 2018-01-01
-Paragraph 39L
-Subparagraph e
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=4&date=2018-03-02&anchor=para_39L_e&doctype=Standard&book=b
-URIDate 2018-03-16

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Name IFRS
-Number 8
-IssueDate 2018-01-01
-Paragraph 23
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=8&date=2018-03-01&anchor=para_23&doctype=Standard
-URIDate 2018-03-16

Reference 7: http://www.xbrl.org/2003/role/exampleRef
-Name IFRS
-Number 12
-IssueDate 2018-01-01
-Paragraph B10
-Subparagraph b
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=12&date=2018-03-01&anchor=para_B10_b&doctype=Appendix&seq=2
-URIDate 2018-03-16

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Name IAS
-Number 1
-IssueDate 2018-01-01
-Paragraph 106
-Subparagraph d
-Clause i
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IAS&num=1&date=2018-03-01&anchor=para_106_d_i&doctype=Standard
-URIDate 2018-03-16

Reference 9: http://www.xbrl.org/2003/role/exampleRef
-Note Effective 2021-01-01
-Name IFRS
-Number 17
-IssueDate 2018-01-01
-Paragraph 113
-Subparagraph b
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IFRS&num=17&date=2018-03-01&anchor=para_113_b&doctype=Standard
-URIDate 2018-03-16

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Name IAS
-Number 1
-IssueDate 2018-01-01
-Paragraph 81A
-Subparagraph a
-URI http://eifrs.ifrs.org/eifrs/XBRL?type=IAS&num=1&date=2018-03-01&anchor=para_81A_a&doctype=Standard
-URIDate 2018-03-16

+ Details

Use of Estimates, Judgments and Assumptions - Additional Information (Detail) - EUR (€)
€ in Thousands

3 Months Ended

6 Months Ended

Jun. 30, 2018

Jun. 30, 2017

Jun. 30, 2018

Jun. 30, 2017

Income tax expenses

€ 87

€ 107

^[1]

€ 139

€ 118

^[1]

United States [member]

Disclosure of changes in accounting estimates [line items]

Income tax expenses

€ 100

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

The aggregate amount included in the determination of profit (loss) for the period in respect of current tax and deferred tax. [Refer: Current tax expense (income); Deferred tax expense (income)]

+ References + Details

Investments - Summary of Investments (Detail) - EUR (€)
€ in Thousands

Jun. 30, 2018

Dec. 31, 2017

Commercial paper [member]

€ 37,077

€ 34,043

^[1]

Non-current investments

16,650

7,060

^[1]

Total investments

53,727

41,103

U.S. Treasury securities [member]

17,715

15,527

Corporate fixed income bonds [member]

2,574

9,177

15,289

7,886

Non-current investments

16,650

7,060

Agency bond [member]

Subclassifications of assets, liabilities and equities [abstract]

€ 1,499

€ 1,453

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Investments - Additional Information (Detail) - EUR (€) € in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2018
Investment [Line Items]
Purchases of investments		€ 29,560
Proceeds from investment maturities		18,931
Foreign currency exchange gains	€ 6,917	4,111
Finance Income Expense [Member]
Investment [Line Items]
Foreign currency exchange gains	€ 3,100	€ 1,900

Trade and Other Receivables - Summary of Trade and Other Receivables Due Within 1 Year (Detail) - EUR (€)
€ in Thousands

Jun. 30, 2018

Dec. 31, 2017

Trade receivables

€ 2,069

€ 1,594

Unbilled receivables

446

710

VAT receivable

622

582

Prepaid expenses

1,640

427

Prepaid pension costs

359

838

Interest bank

275

170

Other receivables

Total

€ 5,477

€ 4,413

^[1]

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Other Liabilities ans Accruals - Summary of Short-term and Payable Within 1 Year (Detail) - EUR (€) € in Thousands	Jun. 30, 2018	Dec. 31, 2017
Disclosure of accruals and other payables [abstract]
Accrued auditor's fee	€ 90	€ 96
Personnel	315	446
R&D costs	8,777	5,272
IP - Legal fee	128	509
Bonuses	940	1,545
Subsidy advance received	145	224
Other accruals	465	535
Total	€ 10,860	€ 8,627

Deferred Revenue - Summary of Deferred Revenue (Detail) - EUR (€)
€ in Thousands

Jun. 30, 2018

Dec. 31, 2017

Disclosure of deferred income [abstract]

Deferred revenue - current portion

€ 16,972

€ 15,935

^[1]

105,718

112,551

^[1]

€ 122,690

€ 128,486

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Deferred Revenue - Additional Information (Detail)
$ / shares in Units, € in Thousands, $ in Thousands

1 Months Ended

3 Months Ended

6 Months Ended

Feb. 13, 2018

USD ($)

$ / shares

Feb. 28, 2017

USD ($)

Jan. 23, 2017

EUR (€)

Jan. 23, 2017

USD ($)

Feb. 28, 2018

EUR (€)

Feb. 28, 2018

USD ($)

Jan. 31, 2017

USD ($)

Jun. 30, 2018

EUR (€)

Jun. 30, 2018

EUR (€)

Jun. 30, 2018

USD ($)

$ / shares

Jun. 30, 2017

EUR (€)

^[1]

Jun. 30, 2018

USD ($)

Dec. 31, 2017

EUR (€)

Purchase price per share | $ / shares

€ 122,690

€ 128,486

$ 18.00

Non-refundable upfront payment received | $

$ 55,800

€ 44,800

$ 55,800

$ 80,000

44,731

€ 74,431

$ 120,000

Upfront and Milestone Payments [member]

Incyte Corporation [member]

Revenue recognized

€ 300

Non-refundable upfront payment receivable | $

$ 120,000

Purchase price per share | $ / shares

3,200,000

$ 25.00

Remaining estimated amortization period

€ 74,700

$ 80,000

7 years 6 months

Incyte Corporation [member] | Deferred revenue [member]

Non-refundable upfront payment received

€ 112,000

Fair value of derivatives

€ 31,400

31,400

Incyte collaboration agreement [member]

Simcere collaboration and license agreement [member]

120,600

Non-refundable upfront payment received

2,000

2,300

$ 2,750

ONO Research and License Agreement [member]

Performance obligation recognized as revenue

100

€ 100

1,100

Paid for full time equivalent funding

200

Compensate for research service

300

ONO Research and License Agreement [member] | Deferred revenue [member]

Non-refundable upfront payment received

€ 700

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Shareholders' Equity - Additional Information (Detail)
€ / shares in Units, $ / shares in Units, $ in Millions

1 Months Ended

3 Months Ended

6 Months Ended

Feb. 15, 2018

EUR (€)

Feb. 15, 2018

USD ($)

Feb. 13, 2018

USD ($)

$ / shares

Jan. 23, 2017

EUR (€)

Jan. 23, 2017

USD ($)

$ / shares

Feb. 28, 2018

EUR (€)

Feb. 28, 2018

USD ($)

Jan. 31, 2017

USD ($)

Jun. 30, 2018

EUR (€)

Mar. 31, 2018

EUR (€)

Jun. 30, 2017

EUR (€)

Jun. 30, 2018

EUR (€)

Jun. 30, 2018

USD ($)

$ / shares

Jun. 30, 2017

EUR (€)

Feb. 13, 2018

€ / shares

Jan. 01, 2018

Dec. 31, 2017

Disclosure of terms and conditions of share-based payment arrangement [line items]

$ 18.00

Issue price per share | € / shares

$ 55.8

€ 44,800,000

$ 55.8

$ 80.0

€ 44,731,000

€ 74,431,000

^[1]

€ 0.09

Foreign currency translation

€ 6,900,000

€ (2,800,000)

€ (12,000,000)

4,100,000

(12,000,000)

Increased capital

3,064

9,978

Increased premium

€ 62,635

€ 216,830

€ 62,635

€ 216,830

Number of share options exercised | shares

34,041

110,869

Number of shares fully issued and paid | shares

€ 1.93

€ 2.05

34,041

110,869

34,041

110,869

Share based payment expense

€ 4,600,000

€ 7,900,000

Option granted | shares

469,068

Weighted-average remaining contractual life

€ 14.24

8 years 2 months 12 days

Weighted-average share price

€ 0

Number of share options outstanding in share-based payment arrangement | shares

2,631,822

2,213,985

Number of new RSUs granted during the period | shares

Top of range [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

Disclosure of terms and conditions of share-based payment arrangement [line items]

€ 1.93

Bottom of range [member]

Incyte Corporation [member]

€ 27.47

Disclosure of terms and conditions of share-based payment arrangement [line items]

3,200,000

$ 25.00

Issue price per share | $ / shares

€ 74,700,000

$ 80.0

$ 25.00

Proceeds from net of issuance costs

74,400,000

Change in fair value asset and discount on share

1,100,000

Foreign currency translation

400,000

Increased capital

300,000

Increased premium

€ 73,400,000

Non-Executive Compensation Program [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

Percentage of initial vesting period

33.00%

Percentage of remaining vesting options

67.00%

Period of remaining option vesting period

24 substantially equal monthly installments

Vesting period

Three-year period

Period of option will be vested and exercised

12 substantially equal monthly installments

Description of grant award

Following the vesting commencement date, such that the subsequent award shall be fully vested on the first anniversary of the date of grant.

2016 Plan [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

Description of options vested

Options granted under the 2016 Plan are exercisable once vested.

Vesting period

4 years

Percentage of initial vesting period

25.00%

Percentage of remaining vesting options

75.00%

Period of remaining option vesting period

36 monthly installments

Percentage of vesting period

100.00%

Description of option lapse

Options will lapse on the tenth anniversary of the date of grant.

Vesting period of Restricted Stock Units vested

4 years

Number of common share entitled to receive | shares

Option granted | shares

469,068

Option grant fair value

€ 4,400,000

Increase in authorized share | shares

1,090,368

777,194

Ordinary shares [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

Number of shares fully issued and paid | shares

22,632,800

19,396,720

22,632,800

19,396,720

Potential ordinary share transactions [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

3,099,997

Aggregate purchase price | $

$ 18.00

$ 55.8

Potential ordinary share transactions [member] | Top of range [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

Received from issuance of private placement | $

$ 55.8

Potential ordinary share transactions [member] | Bottom of range [member]

Disclosure of terms and conditions of share-based payment arrangement [line items]

Received from issuance of private placement

€ 44,800,000

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

Shareholders' Equity - Summary of Inputs Used in the Measurement of the Fair Values and the Related Fair Values at the Grant Dates (Detail)		6 Months Ended
	Feb. 13, 2018 $ / shares	Jun. 30, 2018 € / shares
Disclosure of terms and conditions of share-based payment arrangement [line items]
Share price at grant date \| $ / shares	$ 18.00
Key management personnel [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Expected volatility (weighted-average)		95.10%
Contractual life		10 years
Expected dividends		0.00%
Key management personnel [member] \| Bottom of range [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Fair value at grant date		€ 9.34
Share price at grant date		14.57
Exercise price		€ 14.57
Risk-free interest rate (based on government bonds)		2.79%
Key management personnel [member] \| Top of range [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Fair value at grant date		€ 9.45
Share price at grant date		14.87
Exercise price		€ 14.87
Risk-free interest rate (based on government bonds)		2.94%
All other employees [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Expected volatility (weighted-average)		94.60%
Contractual life		10 years
Expected dividends		0.00%
All other employees [member] \| Bottom of range [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Fair value at grant date		€ 9.30
Share price at grant date		14.57
Exercise price		€ 14.57
Risk-free interest rate (based on government bonds)		2.84%
All other employees [member] \| Top of range [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Fair value at grant date		€ 10.37
Share price at grant date		18.24
Exercise price		€ 18.24
Risk-free interest rate (based on government bonds)		2.94%

Shareholders' Equity - Summary of Reconciliation of Outstanding Share Options (Detail)	6 Months Ended
	Jun. 30, 2018 shares € / shares	Jun. 30, 2017 shares
Disclosure of terms and conditions of share-based payment arrangement [abstract]
Outstanding at January 1 \| shares	2,213,985
Forfeited during the six-month period \| shares	(12,044)
Expired during the six-month period \| shares	(5,146)
Exercised during the six-month period \| shares	(34,041)	(110,869)
Granted during the six-month period \| shares	469,068
Outstanding at June 30 \| shares	2,631,822
Exercisable at June 30 \| shares	1,105,059
Outstanding at January 1 \| € / shares	€ 13.99
Forfeited during the six-month period \| € / shares	19.67
Expired during the six-month period \| € / shares	14.02
Exercised during the six-month period \| € / shares	1.93
Granted during the six-month period \| € / shares	14.68
Outstanding at June 30 \| € / shares	14.24
Exercisable at June 30 \| € / shares	€ 12.18

Shareholders' Equity - Summary of Number of Share Options Outstanding (Detail) - shares	Jun. 30, 2018	Dec. 31, 2017
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of outstanding share options	2,631,822	2,213,985
Key management personnel [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of outstanding share options	2,153,810
All other employees [member]
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of outstanding share options	478,012

Shareholders' Equity - Summary of Reconciliation of RSU's (Detail)	6 Months Ended
	Jun. 30, 2018 EUR (€) shares
Disclosure of terms and conditions of share-based payment arrangement [abstract]
Outstanding beginning balance \| €	€ 20.03
Forfeited during the six month period \| €	0
Vested during the six month period \| €	20.03
Granted during the six month period \| €	0
Outstanding ending balance \| €	€ 20.03
Outstanding beginning balance \| shares	194,546
Forfeited during the six month period \| shares	0
Vested during the six month period \| shares	(76,245)
Granted during the six month period \| shares	0
Outstanding ending balance \| shares	118,301

Revenue - Summary of Revenue (Detail) - EUR (€)
€ in Thousands

3 Months Ended

6 Months Ended

Jun. 30, 2018

Jun. 30, 2017

Jun. 30, 2018

Jun. 30, 2017

Up-front payment amortization [member]

€ 6,543

€ 6,237

^[1]

€ 16,464

€ 10,121

^[1]

Collaboration income [member]

4,250

3,973

9,087

6,898

Revenue from contracts with customers [member]

2,179

1,471

7,195

2,391

Income from grants on research projects [member]

6,429

5,444

16,282

9,289

€ 114

€ 793

€ 182

€ 832

[1]	See Note 3 for details regarding the restatement as a result of a change in accounting policy.

+ References

+ Details

Revenue - Additional Information (Detail) - EUR (€)
€ in Thousands

3 Months Ended

6 Months Ended

12 Months Ended

Jun. 12, 2017

Jun. 30, 2018

Jun. 30, 2017

Jun. 30, 2018

Jun. 30, 2017

Dec. 31, 2017

Payment terms related to receivables

€ 6,543

€ 6,237

^[1]

€ 16,464

€ 10,121

^[1]

Grant income

100

800

€ 200

800

Reimbursement of grant

€ 700

30 days

Revenue recognized included in deferred revenue

€ 7,900

Revenue recognized not included in deferred revenue

1,300

Collaboration income [member]

Incyte collaboration agreement [member]

2,179

1,471

7,195

2,391

Up-front payment amortization

4,000

7,900

6,900

Cost reimbursements

2,000

€ 1,500

4,300

ONO Research and License Agreement [member]

Up-front payment amortization

200

1,100

Cost reimbursements

100

200

€ 2,400

Milestone revenue

2,500

Simcere collaboration and license agreement [member]

Up-front payment amortization

100

Milestone revenue

€ 100

100

IFRS 15 revenue from contracts with customers [member]